
Enhanced Semaglutide formulation with Glycine for injection site comfort and Methylcobalamin B12 for metabolic support. 503A compounded, shipped to clinics in 42 states.
This triple-combination formula adds Glycine (a buffering amino acid for injection site tolerance) and Methylcobalamin B12 (for metabolic support) to the Semaglutide base. It mirrors the enhanced Tirzepatide combination and has become increasingly popular with clinics that want to offer patients a more comfortable injection experience alongside nutrient support during caloric restriction.
This formulation is particularly well-suited for telehealth weight loss programs where patients self-administer at home. The Glycine buffer reduces injection site discomfort, and the B12 supports energy and metabolic function. Clinics that switched to this combination from standalone Semaglutide report improved patient satisfaction scores and lower dropout rates.
Better Patient Experience. Glycine reduces injection site reactions. B12 supports metabolic function. One vial does the work of multiple supplements.Competitive Formulation. This is the same combination profile that top GLP-1 clinics nationwide are adopting.Reliable Supply. High-volume compound with consistent availability through Promise.
The addition of Glycine is the key difference. Glycine acts as a buffering agent that can reduce injection site discomfort, which is a common patient concern with GLP-1 injections.
A single access point for a wide range of 503A formulary products, catering to the requirements of any medical clinic, med spa, or telehealth provider.


At Promise Pharmacy, our dedicated team of hormone health specialists is led by Amy Patel, a seasoned expert in sterile compounding with more than 25 years of experience.